Assistant Professor  |  Cognitive Neurologist

Matthew Burke

Brain and Therapeutics, Consultation/Liaison Psychiatry - Neuropsychiatry


Sunnybrook Health Sciences Centre
2075 Bayview Avenue, FG26, Toronto, Ontario Canada M4N 3M5
Appointment Status


  • B.Sc. (Honours), 2008, Life Sciences, Queen’s University
  • MD, 2012, Medicine, University of Toronto
  • FRCPC, 2017, Neurology, University of Toronto
  • 2019, Cognitive Neurology Fellowship, Harvard Medical School
  • 2019, Harvard Catalyst Clinical and Translational Research Academy, Harvard Medical School

Dr. Matthew Burke is a Cognitive Neurologist in the Neuropsychiatry Program and Department of Psychiatry at Sunnybrook Health Sciences Center. He is currently the Director of Sunnybrook’s Traumatic Brain Injury Clinic and he also sees patients with functional neurological disorders, headache disorders, and other neuropsychiatric conditions. Before starting at Sunnybrook, Dr. Burke completed medical school and his neurology residency training at the University of Toronto, where he was the Chief Neurology Resident in his last year of training. He then completed a two-year Sidney R. Baer, Jr. Foundation fellowship in Cognitive Neurology and Neuropsychiatry at Beth Israel Deaconess Medical Center and Harvard Medical School.

Dr. Burke’s clinical research fellowship provided specialized training in non-invasive brain stimulation and brain network mapping. His research applies these novel techniques to investigate the complex and poorly understood brain disorders at the interface between neurology and psychiatry. He also has research interests in the neurobiology of placebo effects and is an active collaborator with the Harvard Program in Placebo Studies. Finally, concurrent with his fellowship, Dr. Burke completed the Harvard Catalyst Clinical Translational Research Academy. This is a NIH-funded program that provides advanced training in methods of clinical investigation.

Dr. Burke’s research to date has resulted in multiple peer-reviewed publications, media attention on platforms such as CNN and BBC, and recent recognition with the American Neuropsychiatric Association's 2019 Young Investigator Award and the American Headache Society’s 2018 Frontiers in Headache Research Award. 

Research Synopsis

•    Non-invasive Brain Stimulation
•    Brain Network Mapping
•    Concussion and Traumatic Brain Injury
•    Functional Neurological Disorders
•    Migraine
•    Neuroplasticity
•    Placebo Effects

Recent Publications

  1. Burke MJ, Joutsa J, Cohen AL, Soussand L, Cooke D, Burstein R, Fox MD. Mapping Migraine to a Common Brain Network. Brain 2019 [Epub ahead of print]. 
  2. Burke MJ. “It’s All in Your Head” – Medicine’s Silent Epidemic. JAMA Neurology 2019; 2019; 76(12):1417-8. 
  3. Burke MJ, Kaptchuk TJ, Pascual-Leone A. Challenges of differential placebo effects in contemporary medicine: the example of brain stimulation. Ann Neurol. 2019;85(1):12–20.
  4. Fralick M, Sy E, Hassan A, Burke MJ, Mostofsky E, Karsies T. Association of concussion with the risk of suicide: a systematic review and meta-analysis. JAMA Neurol. 2019;76(2):144–151.
  5. Darby RR, Joutsa J, Burke MJ, Fox MD. Lesion network localization of free will. Proc Natl Acad Sci USA. 2018;115(42):10792–9.
  6. Burke MJ, Ghaffar O, Staines WR, Downar J, Feinstein A. Functional neuroimaging of conversion disorder: the role of ancillary activation. Neuroimage Clin. 2014;6:333–39.


Director, Traumatic Brain Injury Clinic, Sunnybrook Health Sciences Centre

Honours and Awards


2019 Young Investigator Award, American Neuropsychiatric Association, USA 

2018 Frontiers in Headache Research Award, American Headache Society, USA  

2018 AAN Fellow Scholarship, American Academy of Neurology, USA  

2017 Marotta Prize for Teaching in Neurology, University of Toronto, Canada

2012 Weber/Nimon Prize in Neurology, University of Toronto, Canada

2011 Mimi and Charles Hollenberg Research Award, University Health Network and Mount Sinai Hospital, Canada